Evaluation of Renoprotective Effects of Ethanolic Extract of Morinda citrifolia L. in a Murine Model of Gentamicin-induced Nephrotoxicity

AIM: The present study was undertaken to evaluate noni fruit juice for its protective effects on gentamicin-induced nephrotoxicity in rats. METHODS:Wistar albino rats of either sex, weighing 150-200g were divided into 4 groups; normal saline, gentamicin 80 mg/kg, i.p.,i for 8 days, noni fruit juice 5 and 10 mg/kg, p.o., for 8 days, noni fruit juice 3 days prior and concurrently with gentamicin for 5 days. Blood urea, serum creatinine, serum uric acid and blood urea nitrogen analyses and microscopic examination of kidney were performed after the treatment. RESULTS: Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in blood urea and serum creatinine. Serum urea, serum uric acid, serum creatinine and blood urea nitrogen were increased with gentamicin compared to saline-treated animals (162.33 ± 9.92mg/dl, 3.13 ± 0.12 mg/dl, 6.85 ± 0.35 mg/dl and 75.86 ± 4.64 mg/dl respectively).Co-administration of noni fruit juice with gentamicin decreased the rise in in these parameters in a dose dependent manner. Study of renal morphology by light microscope showed epithelial loss with intense granular degeneration involving \u3e50% renal cortex in gentamicin treated rats, whereas in noni fruit juice plus gentamicin treated rat revealed insignificant changes in tubular epithelium. CONCLUSION: To conclude, our data suggest that supplementation of noni fruit juice may be useful in reducing gentamicin nephrotoxicity in rats

A Novel Approach for the Design of Controllers with Interleaved Boost Converter

Themomentous increase in exigency of electric energy is forced us to find various source of generations like solar, wind, hydraulic and clean energy like fuel cell. Low cost, high efficiency, compactness, portability and environmentally clean energy has enhanced the research on fuel cell. One of the factor which affects the life time of the fuel cell is ripple content presents in the current. In order to supply high voltage and low current applications, fuel cell is used to integrate with boost converter. But to improve the performance and lifetime of fuel cell, interleaved boost converter is employed. Also to supply for constant load the output voltage has to be maintained at a particular value. To attain this controllers are exploited. The conventional PI controller and smith predictive controller are designed for fuel cell fed interleaved boost converter in order to track the output voltage and to improve the transient time.The results depict the validity of the design procedure and the potential of the proposed method

IOT BASED HEALTH MONITORING SYSTEM

Health monitoring is a major issue in today’s world. Due to the lack of health monitoring, patientssuffer from serious health problems. Health experts are also taking advantage of these smart devices to keepan eye on their projects. Here in this project, we will make an IOT based health monitoring system whichrecords the patient heartbeat rate, body temperature and skin pressure. Heartbeat rate, body temperatureand skin pressure values are recorded over thingspeak and Google sheets so that patient health can bemonitored from anywhere in the world over the internet. We will use Thinspeak to monitor patient heartbeat,temperature and skin pressure online using internet. We will also use IFTTT platform to connect thingspeakto SMS so that alert message can be sent whenever the patient is in critical state

Percutaneous trigger thumb release: a safe push-pull technique

Background: Stenosing tenosynovitis of the thumb is an inflammation of flexor tendon sheath of A1 pulley. Percutaneous release has recently gained popularity. Successful percutaneous release depends upon proper prediction of the location of the A1 pulley and circumventing injury to the neurovascular bundles. The aim of this study was to determine the safety of percutaneous release of trigger thumb.Methods: Twenty eight patients were included in the study between 2015 and 2018. All the patients were percutaneously released using push-pull technique. Steroid injection was given following the release. Quinnell grading, patient questionnaire and visual analogue scale score was used to assess the patients at 2 weeks, 6 weeks and 6 months and 1 year.Results: Satisfactory results were found in 93% of patients. Two patients complained of pain and swelling till third week. No digital nerve injury occurred in any patients.Conclusions: Percutaneous trigger thumb release using this push-pull technique is a simple and a safe technique with very minimal complications.

Unusual medial tibial plateau fracture fixation using dual plating

Background: Medial tibial plateau fractures is a subtype of proximal tibial fractures that involve the articular surface and can present in several distinct patterns. Purpose of this study was to assess the clinical outcome of stabilizing these biplanar medial tibial plateau fractures using dual plating technique through a single incision.Methods: Between 2017 to 2019, 12 men and 8 women with closed medial tibial plateau fracture who underwent reconstruction using two plates through a posteromedial approach were included in the study group. The fractures were classified using the three column concept of Lou.Results: One patient had an articular step off that was unacceptable and two patients had an acceptable articular step off. Functional assessment was done using the objective scoring of Oxford knee score criteria and radiological assessment was done using the Rasmussen modified score.Conclusions: Biplanar reconstruction using dual plates is a reliable and safe technique to reconstruct complex medial tibial plateau fractures

Evaluation of polyhalite on growth, yield attributes and yield of blackgram (Vigna mungo L.)

Potassium is involved in a diverse range of processes within plants that are needed for their growth, yield and better quality. The polyhalite as a hydrated evaporate mineral that can be used directly as a source of potassic fertilizer. However, research on polyhalite's appropriateness and effectiveness, the present investigation aimed to evaluate the effect of polyhalite on growth, yield attributes, and yield of blackgram variety ADT 5 at Chinnakandiankuppam village, Vriddhachalam, Cuddalore district, Tamil Nadu, during 2021. The experiment was laid out in randomized block design consisting of ten treatments viz., T1 (absolute control), T2 (-K), T3 (12.5 kg K2O ha-1 as muriate of potash (MOP)), T4 (25 kg K2O ha-1as MOP), T5 (37.5 kg K2O ha-1 as MOP), T6 (50 kg K2O ha-1 as MOP), T7 (12.5 kg K2O ha-1 as polyhalite),  T8 (25 kg K2O ha-1 as polyhalite), T9 (37.5 kg K2O ha-1 as polyhalite), T10 (50 kg K2O ha-1 as polyhalite). The experiment revealed that the application of 37.5 kg K2O ha-1 as polyhalite (T9) significantly (5%) enhanced the growth attributes (plant height (38.7 cm), number of branches plant-1 (12.97), leaf area index (2.13), number of nodules plant-1 (18.76) and dry matter production (1972 hg ha-1), yield attributes (pod length (8.21 cm), number of pods plant-1 (20.05), number of seeds pod-1 (7.14) and test weight (3.53 g)) and grain yield (1439 kg ha-1), haulm yield (1876 kg ha-1) of blackgram. Thus the study would be helpful to farmers for yield maximization of blackgram through polyhalite as potassic fertilizer.    

Dynamic Fabry-Perot cavity stabilization technique for atom-cavity experiments

We present a stabilization technique developed to lock and dynamically tune the resonant frequency of a moderate finesse Fabry-P\'erot (FP) cavity used in precision atom-cavity quantum electrodynamics (QED) experiments. Most experimental setups with active stabilization either operate at one fixed resonant frequency or use transfer cavities to achieve the ability to tune the resonant frequency of the cavity. In this work, we present a simple and cost-effective solution to actively stabilize an optical cavity while achieving a dynamic tuning range of over 100 MHz with a precision under 1 MHz. Our unique scheme uses a reference laser locked to an electro-optic modulator (EOM) shifted saturation absorption spectroscopy (SAS) signal. The cavity is locked to the PDH error signal obtained from the dip in the reflected intensity of this reference laser. Our setup provides the feature to efficiently tune the resonant frequency of the cavity by only changing the EOM drive without unlocking and re-locking either the reference laser or the cavity. We present measurements of precision control of the resonant cavity frequency and vacuum Rabi splitting (VRS) to quantify the stability achieved and hence show that this technique is suitable for a variety of cavity QED experiments

CLINICAL OUTCOME OF CALCIUM, VITAMIN D3 & PHYSIOTHERAPY IN OSTEOPOROTIC POPULATION IN THE NILGIRIS DISTRICT

Objective: Osteoporosis and associated fractures are an important cause of mortality and morbidity. The aim of the study is to evaluate the effects of different treatment modalities calcium, calcium+VitD3 and calcium+physiotherapy and finds their effects on the quality of life in osteoporotic patients using International Osteoporosis Foundation Qualeffo-41Questionnaire and calculates the prevalence in the study sites.Methods: An open, randomized study comparing the effect of three treatment modalities was carried out in 100 patients (expecting 20%drop out) for six months between September 2013 and March 2014.Results: On the evaluation of 82 patients for 6 mo it showed that prevalence of osteoporosis is 4.82% in Nilgiris district, TamilNadu. Among the different domains of QUALEFFO-41questionnaire of osteoporotic international foundation (IOF), patients treated with calcium were effective in improving leisure, social activity (at P<0.01). Calcium &physiotherapy was found to be effective in improving mobility and pain (at P<0.0001). But Calcium & Vitamin D3 group proved to be effective in improving Physical function like activities of daily living (at P<0.001).Conclusion: Osteoporotic population taking calcium along with physiotherapy showed an improvement in the total quality of life.Keywords: Osteoporosis, QOL, Calcium, Vitamin D3, Physiotherapy, Nilgiris, QUALEFFO-41questionnair